Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Vasopressor systems during smoking in humans.

R Dietz, A Schömig, K Kusterer

Klinische Wochenschrift

|January 1, 1984

Summary

Cigarette smoking did not directly correlate with angiotensin II or vasopressin levels, but did show a negative link with norepinephrine and heart rate. Beta blockade did not fully prevent smoking-induced cardiovascular changes.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Stem Cell Therapy after Acute Myocardial Infarction-The Emperor's New Clothes?: Stem Cell Mobilization by Granulocyte Colony-Stimulating Factor in Patients with Acute Myocardial Infarction: A Randomized Controlled Trial. JAMA 295: 1003-1010, 2006.

Journal of the American Society of Nephrology : JASN·2023

Same author

Effects of maternal anxiety and depression during pregnancy in Chinese women on children's heart rate and blood pressure response to stress.

Journal of human hypertension·2015

Same author

Circulating vitamin D levels are associated with the presence and severity of coronary artery disease but not peripheral arterial disease in patients undergoing coronary angiography.

Nutrition, metabolism, and cardiovascular diseases : NMCD·2015

Same author

A gender-specific analysis of association between hyperuricaemia and cardiovascular events in patients with coronary artery disease.

Nutrition, metabolism, and cardiovascular diseases : NMCD·2013

Same author

The impact of smoking on the antiplatelet action of clopidogrel in non-ST-elevation myocardial infarction patients: results from the ISAR-REACT 4 platelet substudy.

Journal of thrombosis and haemostasis : JTH·2012

Same author

Erythropoietin-induced progenitor cell mobilisation in patients with acute ST-segment-elevation myocardial infarction and restenosis.

Thrombosis and haemostasis·2012

Area of Science:

Cardiovascular Physiology
Human Physiology
Pharmacology

Background:

Cigarette smoking impacts cardiovascular function.
The role of vasopressor systems and sympathetic activity during smoking is not fully understood.

Purpose of the Study:

To investigate the correlation between cigarette smoking, vasopressor systems, and hemodynamic changes.
To compare these effects with physical exercise and norepinephrine infusion.
To explore the impact of beta-blockade on smoking-induced cardiovascular responses.

Main Methods:

Correlating plasma angiotensin II, vasopressin, and norepinephrine with heart rate and blood pressure during smoking.
Comparing smoking effects with physical exercise and norepinephrine infusion.
Administering beta-blockade (metoprolol) before smoking to assess its effect on sympathetic stimulation.

Main Results:

No significant relationship found between angiotensin II or vasopressin and hemodynamic parameters, despite a slight increase in these hormones during smoking.
A negative correlation was observed between heart rate and plasma norepinephrine during smoking (r = -0.245).
Beta-blockade lowered baseline heart rate and blood pressure but did not abolish smoking-induced increases.

Conclusions:

Nicotine's effect on sympathetic stimulation and norepinephrine at postsynaptic receptors during smoking in humans remains unproven.
Smoking elicits cardiovascular responses that are not solely mediated by direct increases in plasma angiotensin II or vasopressin.
Further research is needed to elucidate the precise mechanisms of nicotine's cardiovascular effects.

Related Experiment Videos