Effect of alkaloids of Solanum melongena on the central nervous system

Crude alkaloidal fraction isolated from the leaves of Solanum melongena was screened for its effects on the central nervous system. It exhibited significant analgesic effect and some CNS depression but no anticonvulsant action. The analgesic effects were of non-narcotic type. LD50 was estimated to be higher than 1 g/kg i.p. in mice.