Modification in the antibody-dependent cellular cytotoxicity as influenced by chemicals

With the increased use of chemicals in health related sciences, there is a need for a better understanding as to how these chemicals interact with the immune system. The purpose of this review was to bring together published information on the effects chemicals have on antibody-dependent cellular cytotoxicity (ADCC). This immunoeffector mechanism requires the interaction of both the humoral (antibody) and cellular components (expressing Fc receptors on the plasma membrane) with the specificity being determined by the antibody. Most of the chemicals tested and mentioned in this review are those that are currently used in chemotherapy, antibiotic and drug regimes and in the maintenance of anesthesia. The major point that emerges from this review is that while a great deal of information has been obtained, there is also a good deal of conflicting information. Furthermore, the mechanisms of action are not fully understood or are unknown in many cases. Further work, therefore, is needed to ascertain the importance and relevance of these chemicals in interfering with the ADCC phenomenon and the mode of action of these chemicals within the ADCC mechanism.