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Related Experiment Videos

Laryngeal pressure receptors.

O P Mathew, G Sant'Ambrogio, J T Fisher

    Respiration Physiology
    |July 1, 1984
    PubMed
    Summary

    This study identified laryngeal pressure receptors in dogs that respond to airway pressure changes. These receptors likely play a role in normal breathing and conditions like obstructive sleep apnea.

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    Area of Science:

    • Respiratory Physiology
    • Neuroscience
    • Mechanoreceptor Biology

    Background:

    • The upper airway is crucial for breathing and is susceptible to pressure variations.
    • Laryngeal mechanoreceptors are implicated in respiratory control but their precise function requires further elucidation.

    Purpose of the Study:

    • To characterize the response properties of laryngeal pressure receptors in anesthetized dogs.
    • To investigate the potential role of these receptors in eupnea and pathological conditions like obstructive sleep apnea.

    Main Methods:

    • Recording single unit action potentials from the superior laryngeal nerve in isolated canine larynx.
    • Applying controlled positive and negative pressures to the isolated upper airway.
    • Analyzing receptor sensitivity, adaptation, and activity patterns relative to transmural pressure.

    Main Results:

    • Identified laryngeal mechanoreceptors responding to positive, negative, or both pressure types.
    • Receptors exhibited dynamic sensitivity and characteristics of slowly adapting mechanoreceptors.
    • Majority of receptors were active at zero transmural pressure with higher gain at lower pressures.

    Conclusions:

    • Laryngeal pressure receptors are sensitive to airway pressure fluctuations.
    • These receptors likely contribute to the regulation of normal breathing (eupnea).
    • They may mediate reflex responses to airway pressure changes and play a role in obstructive sleep apnea.

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