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Reference intervals for urinary glucose in pregnancy.

H Mortensen, L Mølsted-Pedersen, L Schmølker

    Scandinavian Journal of Clinical and Laboratory Investigation
    |September 1, 1984
    PubMed
    Summary
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    Urine glucose reference limits are higher in pregnant women and increase with gestational age. Standard reagent strips show variable accuracy in detecting glucosuria within these elevated ranges.

    Area of Science:

    • Clinical Chemistry
    • Reproductive Medicine
    • Urine Analysis

    Background:

    • Establishing accurate reference intervals for urine glucose is crucial for monitoring gestational diabetes and other conditions.
    • Previous studies have indicated potential differences in urine glucose levels between pregnant and non-pregnant individuals.

    Purpose of the Study:

    • To determine the upper reference limits for urine glucose in non-fasting pregnant women.
    • To evaluate the performance of common reagent strips (Tes-Tape and Uristix) in detecting glucosuria within these established limits.

    Main Methods:

    • Urine samples from non-fasting pregnant women were analyzed using a glucose dehydrogenase method.
    • Reference intervals were established based on gestational age.
    • The sensitivity of Tes-Tape and Uristix reagent strips was assessed against known glucose concentrations.

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    Main Results:

    • Upper reference limits for urine glucose in pregnant women were found to be higher than in non-pregnant women (1.4 mmol/l).
    • These limits increased with gestational age: 2.0 mmol/l (weeks 10-20), 2.3 mmol/l (weeks 21-30), and 2.7 mmol/l (weeks 31-42).
    • Tes-Tape detected glucosuria above 7 mmol/l and reacted with 66% of samples between the upper reference interval and 8 mmol/l, while Uristix showed no positive reactions.

    Conclusions:

    • Reference intervals for urine glucose are significantly influenced by pregnancy and gestational age.
    • Standard urine glucose reagent strips exhibit variable sensitivity, potentially leading to underestimation of glucosuria in pregnant women, particularly with Tes-Tape and Uristix.