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Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
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[Limiting values of serum thyroglobulin observed in athyrosis]
Abstract:
Investigations in 6 cases of congenital or acquired athyreosis show that serum thyroglobulin determined in these cases by radioimmunology is not due to a determination artifact or to another protein, but that, with regard to immunoreactivity, molar mass and isoelectric point, it displays all the features of the standard thyroglobulin of thyroid origin and of the serum thyroglobulin of normal subjects. The authors conclude that small quantities of thyroglobulin are present in the serum of such patients, even where all the other criteria of athyrosis appear to be present.
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