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[How to treat hyperuricemia?].

H Favre

    Schweizerische Medizinische Wochenschrift
    |September 15, 1984
    PubMed
    Summary
    This summary is machine-generated.

    High uric acid levels affect 21.5% of men, often with other health issues. Treatment for asymptomatic hyperuricemia is generally not recommended due to risks, but may be considered for severe gout or kidney stones.

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    Cell shrinkage triggers the activation of mitogen-activated protein kinases by hypertonicity in the rat kidney medullary thick ascending limb of the Henle's loop. Requirement of p38 kinase for the regulatory volume increase response.

    The Journal of biological chemistry·1999

    Area of Science:

    • Biochemistry
    • Clinical Medicine
    • Epidemiology

    Context:

    • Hyperuricemia, defined as elevated blood uric acid levels, is prevalent in a significant portion of the male population.
    • A notable percentage of men with hyperuricemia also exhibit other abnormal biological parameters, suggesting a complex metabolic profile.
    • These individuals clinically differ from normo-uricemic subjects, presenting with variations in weight, blood pressure, and a tendency towards diabetes.

    Purpose:

    • To evaluate the clinical significance and management implications of asymptomatic hyperuricemia in a general population.
    • To differentiate the risks associated with hyperuricemia itself versus its association with other metabolic derangements.
    • To provide evidence-based guidance on the indications for treating hyperuricemia.

    Summary:

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    • 21.5% of men exhibit hyperuricemia (uric acid > 6.8 mg%).
    • Half of hyperuricemic men have other elevated biological markers and clinical differences including weight, blood pressure, and diabetes risk.
    • Hyperuricemia alone is not a risk factor for renal/vascular diseases, but correlates with gouty arthritis and urinary stones.

    Impact:

    • Findings suggest that treatment for asymptomatic hyperuricemia should be avoided due to potential drug side effects.
    • The study highlights that indications for treatment are limited to recurrent, poorly tolerated urolithiasis or arthritis.
    • This research informs clinical practice regarding the judicious management of elevated uric acid levels.