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Cilia in the human kidney.

S M Katz, J J Morgan

    Ultrastructural Pathology
    |January 1, 1984
    PubMed
    Summary
    This summary is machine-generated.

    Multiple cilia with a 9+2 microtubular pattern were found in the renal tubules of adult nephrotic syndrome patients. This finding, also observed in fetuses, highlights the presence of diverse cilia structures in human kidneys.

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    Area of Science:

    • Nephrology
    • Cell Biology
    • Pathology

    Background:

    • The presence and function of cilia in adult human renal tubules are not fully understood.
    • Previous reports have documented renal tubular cilia in specific syndromes, but their broader occurrence is less clear.

    Observation:

    • Transmission electron microscopy revealed multiple cilia exhibiting a 9+2 microtubular axoneme structure in the renal tubules of four adult patients with nephrotic syndrome.
    • These patients presented with diverse underlying renal pathologies, including amyloidosis, lipoid nephrosis, membranoproliferative glomerulonephritis, and focal segmental glomerulosclerosis.
    • Similar ciliary structures were also identified in the metanephric tubules of all examined human fetuses.

    Findings:

    • The study confirms the presence of 9+2 patterned cilia in adult renal tubules, extending beyond previously identified conditions.

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  • This finding suggests that such ciliary structures are not exclusive to specific diseases or developmental stages.
  • The observation in multiple fetuses indicates a potential developmental role or baseline presence of these cilia.

    • Implications:

    • Pathologists should recognize the occurrence of multiple cilia with 9+2 architecture in adult kidneys, irrespective of the specific nephrotic syndrome diagnosis.
    • This finding may necessitate a re-evaluation of the diagnostic significance of renal tubular cilia in kidney diseases.
    • Further research is warranted to elucidate the functional role and clinical relevance of these cilia in adult renal physiology and pathology.