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[Subchronic toxicity testing of mold-ripened cheese]
Abstract:
The biological effects of known mycotoxins of Penicillium roqueforti or P. camemberti and other still unknown, but potentially toxic metabolites in mould ripened cheese (commercial samples of Blue- and Camembert cheese) were investigated. High amounts of mycelium (equivalents of 100 kg cheese/man and day) were fed to mice in a subchronic feeding trial. The following parameters were determined: development of body weight, organ weights, hematology, blood plasma enzymes. No signs of adverse effects produced by cheese mycotoxins could be detected after 28 days. No still unknown toxic metabolites could be demonstrated. From these results no health hazard from the consumption of mould ripened cheese, even in high amounts, appears to exist.
Insights
Consumption of mold-ripened cheeses like Blue and Camembert, even in high amounts, poses no health hazard. Studies found no adverse effects from mycotoxins or unknown metabolites in mice over 28 days.
Area of Science:
- Food safety and toxicology
- Microbiology of fermented foods
Context:
- Mould-ripened cheeses, such as Blue and Camembert, are produced using Penicillium roqueforti or P. camemberti.
- These cheeses may contain mycotoxins and potentially toxic metabolites from these moulds.
Purpose:
- To investigate the biological effects of known and unknown metabolites in mould-ripened cheeses.
- To assess the safety of consuming high quantities of these cheeses.
Summary:
- A 28-day subchronic feeding trial involved administering high amounts of mould-ripened cheese mycelium to mice.
- Key parameters monitored included body weight, organ weights, hematology, and blood plasma enzymes.
- No adverse effects were detected, and no unknown toxic metabolites were identified.
Impact:
- Provides evidence that consumption of mould-ripened cheeses, even in large quantities, does not present a health risk.
- Reassures consumers about the safety of Blue and Camembert cheeses regarding mycotoxin exposure.
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