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Related Experiment Videos

Enflurane, isoflurane and the eye.

G Earnshaw

    Acta Anaesthesiologica Scandinavica
    |August 1, 1984
    PubMed
    Summary

    Both enflurane and isoflurane anesthesia significantly decreased intra-ocular pressure in patients. Isoflurane provides a viable alternative to enflurane when monitoring eye pressure during surgery is critical.

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    Area of Science:

    • Ophthalmology
    • Anesthesiology
    • Pharmacology

    Background:

    • Intra-ocular pressure (IOP) management is crucial in ophthalmic surgery.
    • Inhaled anesthetics can influence IOP, necessitating careful agent selection.
    • Nitrous oxide/oxygen anesthesia is commonly used, often supplemented with volatile agents.

    Purpose of the Study:

    • To compare the effects of enflurane and isoflurane on intra-ocular pressure when used as supplements to nitrous oxide/oxygen anesthesia.
    • To determine if one agent offers a superior profile for IOP reduction in this context.

    Main Methods:

    • A prospective study involving 20 ophthalmological patients.
    • Patients received nitrous oxide/oxygen anesthesia supplemented with either 1% enflurane (n=10) or 0.7% isoflurane (n=10), equivalent to 0.6 MAC.
    • Intra-ocular pressure was monitored throughout the procedure.

    Main Results:

    • Both enflurane and isoflurane significantly reduced intra-ocular pressure.
    • Enflurane decreased IOP by a mean of 3.1 mmHg (0.4 kPa).
    • Isoflurane decreased IOP by a mean of 2.1 mmHg (0.3 kPa).
    • No statistically significant difference in IOP reduction was observed between the two agents.

    Conclusions:

    • Both enflurane and isoflurane are effective in lowering intra-ocular pressure when used with nitrous oxide/oxygen anesthesia.
    • Isoflurane presents a suitable alternative to enflurane for ophthalmic procedures where maintaining lower intra-ocular pressure is important.

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