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Related Experiment Videos

Extratubular efflux and nephropathy.

H Shigematsu, S Murakami, B Akikusa

    Acta Pathologica Japonica
    |July 1, 1984
    PubMed
    Summary
    This summary is machine-generated.

    Periodic acid-Schiff (PAS) positive material indicates intrarenal reflux. This reflux is linked to hydronephrosis and interstitial changes, suggesting a role in renal tissue injury.

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    Area of Science:

    • Nephrology
    • Histopathology
    • Urology

    Background:

    • Extratubular efflux of periodic acid-Schiff (PAS) positive material is a histological marker for intrarenal reflux.
    • Intrarenal reflux is implicated in various kidney pathologies.

    Purpose of the Study:

    • To analyze the correlation between PAS positive material and interstitial/glomerular changes in surgical renal specimens.
    • To investigate the incidence and distribution of extratubular PAS positive material in different renal conditions.

    Main Methods:

    • Histological analysis of 114 surgical specimens including renal calculi, hydronephrosis, and vesicoureteral reflux.
    • Evaluation of extratubular PAS positive material, interstitial mononuclear cell infiltration, and glomerular lesions.

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    Main Results:

    • Higher incidence of extratubular efflux observed in hydronephrotic kidneys.
    • PAS positive material found in interstitium, venous, and lymphatic spaces.
    • Moderate hydronephrosis showed more interstitial infiltration and PAS material than renal calculi.
    • Global glomerular sclerosis was the most common lesion, with some segmental sclerosis and crescentic reactions.

    Conclusions:

    • Intrarenal reflux, indicated by extratubular PAS material, is associated with significant renal tissue damage.
    • Hydronephrosis appears to be a condition with a higher prevalence of intrarenal reflux and associated histological changes.
    • The findings suggest intrarenal reflux plays a crucial role in the pathogenesis of diverse renal injuries.