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Updated: May 11, 2026

Modeling Colitis-Associated Cancer with Azoxymethane (AOM) and Dextran Sulfate Sodium (DSS)
Published on: September 11, 2012
Acromegaly and colon cancer
Patients with acromegaly show a higher incidence of colon cancer and polyps. This study investigated 13 acromegaly patients, finding increased risks for colorectal conditions.
Area of Science:
- Endocrinology
- Gastroenterology
- Oncology
Background:
- Acromegaly is a condition caused by excess growth hormone.
- Previous studies suggest a link between acromegaly and gastrointestinal polyps.
Purpose of the Study:
- To investigate the incidence of colon cancer and polyps in patients with acromegaly.
- To determine if acromegaly increases the risk of colorectal neoplasia.
Main Methods:
- A study of 13 patients with acromegaly was conducted.
- Colonoscopies were performed on 8 patients.
- Barium enema was used for one patient.
Main Results:
- Two patients were diagnosed with colon cancer (including the index case).
- Two patients had adenomatous polyps, and one had hyperplastic polyps.
- One patient had a presumptive sigmoid polyp.
Conclusions:
- The findings support previous data linking acromegaly to colon polyps.
- The incidence of colon cancer appears higher than expected in acromegaly patients.
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