[Kidney function and mitochondrial metabolism in excluded renal blood flow against a background of diuretic action]

Single administration of furosemid, etacrine acid and mannitol prior to switching off circulation in the only kidney for 2.5 hrs preserves the renal tissue from ischemic lesion, aids to normalizing the excretory processes on the 2nd--4th days of postischemic period, reduces duration of the oligo--anuric phase in acute renal insufficiency, and raises survival rate in the rats. The above substances are ineffective if administered after cessation of the ischemic period. Etacrin acid and novurit suppress functional activity of isolated mitochondria incubated in hypoxia at 37 degrees. Furosemid and mannitol in these conditions exert no effect. Preliminary administration of furosemid aids to preservation of lumen in proximal tubules of superficial nephrones both during cessation of the renal circulation and in the postischemic period.