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Family resemblance for normal pulmonary function.

E J Devor, M H Crawford

    Annals of Human Biology
    |September 1, 1984
    PubMed
    Summary
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    Family resemblance in pulmonary function (forced vital capacity and forced expiration volume) is influenced by transmissible factors (20-30%) and sibling environment effects. Same-sex siblings show stronger correlations than opposite-sex siblings.

    Area of Science:

    • Quantitative genetics
    • Pulmonary medicine
    • Human genetics

    Background:

    • Pulmonary function, including forced vital capacity (FVC) and forced expiration volume in one second (FEV1.0), exhibits familial resemblance.
    • Understanding the sources of this resemblance is crucial for identifying genetic and environmental influences on respiratory health.

    Purpose of the Study:

    • To assess family resemblance for normal pulmonary function using a path analysis model.
    • To investigate sex differences in the transmissibility of pulmonary function phenotypes.
    • To examine the influence of correlated shared-sibling environments on pulmonary function resemblance.

    Main Methods:

    • Utilized the XTAU path analysis model to analyze familial correlations for FVC and FEV1.0.
    • Incorporated parameters for parent-offspring transmissibility and shared-sibling environmental effects.

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  • Accounted for potential sex-specific effects in the sibling environment.

    • Main Results:

    • Transmissible factors (genetic or cultural) account for 20-30% of the variation in pulmonary function measures.
    • A significant same-sex-specific sibling environmental effect was identified, increasing same-sex sibling correlations and decreasing opposite-sex sibling correlations.
    • Results align with twin study findings indicating high heritability for FVC and FEV1.0.

    Conclusions:

    • Family resemblance in pulmonary function is influenced by both heritable factors and sibling environmental dynamics.
    • The sibling environment exerts a same-sex-specific effect, highlighting its importance in shaping respiratory health.
    • These findings have implications for understanding the etiology of pulmonary disorders like asthma and COPD.