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Familial acanthosis nigricans.

D Tasjian, M Jarratt

    Archives of Dermatology
    |October 1, 1984
    PubMed
    Summary

    Benign familial acanthosis nigricans is a genetic skin condition appearing in childhood and worsening at puberty. This eruption is unrelated to other illnesses, unlike other forms of acanthosis nigricans.

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    Area of Science:

    • Dermatology
    • Genetics
    • Pediatrics

    Background:

    • Acanthosis nigricans (AN) is a dermatological condition characterized by hyperpigmentation and thickening of the skin.
    • Familial forms of AN suggest a genetic predisposition.
    • Distinguishing benign familial AN from secondary AN is crucial for diagnosis and management.

    Observation:

    • A mother and daughter presented with benign familial acanthosis nigricans.
    • The condition began in early childhood and was exacerbated during puberty.
    • The eruption was not linked to any underlying systemic diseases.

    Findings:

    • Benign familial acanthosis nigricans is an inherited condition.
    • Onset in childhood with pubertal accentuation is characteristic.
    • Absence of associated comorbidities differentiates it from other AN subtypes.

    Implications:

    • Early diagnosis of benign familial AN prevents unnecessary investigations for secondary causes.
    • Understanding the genetic basis aids in family counseling and risk assessment.
    • This benign form highlights the diverse etiology of acanthosis nigricans.

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