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The acquired cutaneous mucinoses.

L Y Matsuoka, J Wortsman, K S Carlisle

Archives of Internal Medicine

|October 1, 1984

Summary

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Skin glycosaminoglycan (GAG) deposits in thyroid disorders, scleromyxedema, and scleredema share similar hyaluronic acid composition. Fibroblast activity differs, suggesting local causes for scleredema/scleromyxedema and systemic origins for thyroid-related GAG infiltration.

Area of Science:

Dermatology
Endocrinology
Histopathology

Background:

Glycosaminoglycan (GAG) infiltration characterizes various skin conditions, including thyroid disorders and mucinoses.
Understanding the pathogenesis of these GAG deposits is crucial for differentiating these conditions.

Purpose of the Study:

To investigate the pathogenesis of skin GAG deposits in hyperthyroidism, hypothyroidism, pretibial myxedema, scleromyxedema, and scleredema.
To compare the GAG composition, distribution, and fibroblast activity across these acquired cutaneous mucinoses.

Main Methods:

Light microscopy and electron microscopy were employed to examine skin tissue.
Histochemical digestion with GAG-specific enzymes was performed to identify the types and distribution of GAGs.
Dermal fibroblast activity was assessed morphologically.

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Main Results:

Hyaluronic acid was identified as the predominant GAG in all investigated conditions, including normal skin.
Minimal variability was observed in the dermal distribution of GAGs across the conditions.
Dermal fibroblasts were inactive in thyroid disorders but hypertrophic/hyperplastic in scleromyxedema and scleredema.

Conclusions:

Acquired cutaneous mucinoses share similar GAG distribution and biochemical composition.
Differences in fibroblast activity suggest a local pathogenesis for scleromyxedema and scleredema.
GAG infiltration in thyroid diseases likely originates from a systemic process.