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[African histoplasmosis. A case].

C André, J Badoual, G Kalifa

    Archives Francaises De Pediatrie
    |June 1, 1984
    PubMed
    Summary
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    This case highlights severe disseminated African histoplasmosis (Histoplasma duboisii) in a child, presenting with lymphadenopathy, skin nodules, and aggressive bone lesions. Early recognition is crucial to differentiate it from other bone infections and osteosarcoma.

    Area of Science:

    • Mycology
    • Infectious Diseases
    • Pediatrics

    Background:

    • African histoplasmosis, caused by Histoplasma duboisii, is a rare fungal infection.
    • Disseminated forms are less common but can present with severe systemic involvement.

    Observation:

    • A 12-year-old girl from Cameroon presented with severe disseminated African histoplasmosis.
    • Clinical manifestations included diffuse lymphadenopathy, facial and trunk skin nodules, and suppurative osteoarticular lesions.
    • Radiological findings revealed extensive bone lysis and metaphyseal fractures without signs of reconstruction.

    Findings:

    • The case demonstrates a severe disseminated presentation of Histoplasma duboisii infection.
    • Osteoarticular lesions showed aggressive bone destruction, mimicking other conditions.

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  • The disseminated lesions posed diagnostic challenges, potentially confused with multifocal bone lesions in sickle-cell disease.

    • Implications:

    • Highlights the importance of recognizing African histoplasmosis, particularly in endemic regions.
    • Emphasizes the need for differential diagnosis in cases of infectious osteoarthritis and bone lesions.
    • Underscores the potential severity and diagnostic complexity of disseminated Histoplasma duboisii infections in children.