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Serum creatine kinase B concentrations in acute cerebrovascular diseases

F E Pfeiffer, H A Homburger, T Yanagihara

    Archives of Neurology
    |November 1, 1984
    PubMed

    Insights

    Serum creatine kinase B (CKB) levels fluctuate significantly after ischemic stroke, correlating with tissue damage. These CKB changes help differentiate stroke types and severity in patients.

    Area of Science:

    • Neurology
    • Biochemistry

    Background:

    • Serum creatine kinase B (CKB) is an enzyme relevant to cellular energy metabolism.
    • Understanding CKB dynamics in cerebrovascular diseases can aid in diagnosis and prognosis.

    Purpose of the Study:

    • To investigate the diagnostic and prognostic value of serum CKB concentrations in acute cerebrovascular diseases.
    • To analyze CKB fluctuations in relation to stroke type, severity, and clinical events.

    Main Methods:

    • Serum CKB levels were measured every 12 hours for five days in 38 patients with acute cerebrovascular diseases and 9 controls.
    • CKB concentrations were correlated with stroke volume, type (ischemic infarction, transient vascular events, subarachnoid hemorrhage), and clinical outcomes.

    Main Results:

    • Elevated and fluctuating CKB concentrations were observed in patients with acute cerebral infarction, correlating with tissue damage volume.
    • Normal CKB profiles were noted in patients with transient vascular events.
    • Patients with subarachnoid hemorrhage showed wide CKB fluctuations and high concentrations, sometimes linked to angiography or clinical worsening.

    Conclusions:

    • Serum CKB monitoring can help differentiate between ischemic stroke, transient vascular events, and subarachnoid hemorrhage.
    • CKB fluctuation patterns, particularly in ischemic stroke, may serve as a biomarker for infarct size.
    • CKB changes in ischemic stroke were not associated with neurological worsening or recurrent events.

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