[Effect of antigenic stimulation and fasting on liver lysosomes in rats]

Study of the interrelationship between immune responsiveness of the body and structural and functional status of the rat liver lysosomal apparatus under different alimentary conditions allowed one to establish that immune response during antigenic stimulation and complete fasting was considerably reduced. At the same time a dramatic rise in the total and non-sedimentable activities of some lysosomal hydrolases was recorded under the above conditions. The data obtained suggest that during acute malnutrition and antigenic stimulation, the rate of antibody synthesis is considerably decreased whereas activation of the lysosomal apparatus affected by both factors plays a compensatory role and is directed toward the most complete realization of the protective function of lysosomes.