Intraglomerular metastases. Report of two cases

Area of Science:

• Nephrology
• Oncology
• Pathology

Background:

• Glomerular metastases are exceptionally rare findings in renal pathology.
• Understanding the mechanisms of cancer spread to the glomeruli is crucial for diagnosis and treatment.

Observation:

• Two distinct cases of glomerular metastases were documented.
• One case involved a patient diagnosed via kidney needle biopsy showing proteinuria.
• The second case was identified during an autopsy.

Findings:

• Histologic examination revealed intracapillary glomerular metastasis in one patient.
• The other patient presented with associated intra- and extracapillary glomerular metastases.
• Microscopic analysis included light microscopy, immunofluorescence, and electron microscopy.

Implications:

• These rare cases highlight the need for improved early detection strategies for glomerular metastases.
• Further research is required to understand the origin of primary tumors and the pathways of malignant dissemination to the glomeruli.
• Investigating glomerular localization mechanisms can offer insights into renal cancer progression.