Photometric studies on nuclear DNA content and area in different laryngeal epithelia

A photometric study of different laryngeal epithelia was performed. The nuclear DNA content and area for epithelia with keratosis, hyperplasia, and moderate dysplasia were comparable to normal. These lesions cannot therefore be considered to be premalignant photometrically. The photometric values for carcinoma in situ and severe dysplasia were comparable to that for invasive carcinoma. Long-term follow-up has to be performed to evaluate the biological significance of these different lesions.