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Evaluation of a paper-patch test for sweat chloride determination
Clinical Pediatrics
|November 1, 1984
Summary
The new sweat patch test (SPT) accurately identifies cystic fibrosis by detecting elevated sweat chloride levels. This simple, portable test shows promise as an effective screening tool for cystic fibrosis.
Area of Science:
- Medical Diagnostics
- Biochemistry
Background:
- Cystic Fibrosis (CF) diagnosis relies on sweat chloride testing.
- A novel, qualitative sweat patch test (SPT) has been developed for CF screening.
Purpose of the Study:
- To evaluate the diagnostic accuracy and reliability of the newly developed SPT.
- To assess SPT's utility as a screening tool for cystic fibrosis.
Main Methods:
- The SPT utilizes a battery-powered stimulator and electrodes to induce sweating.
- A paper patch collects sweat, indicating chloride levels above 40-50 mEq/l via color change.
- The test was administered to 66 CF patients, 75 controls, and 37 relatives.
Main Results:
- No false-negative results were observed in the 66 cystic fibrosis patients.
- 71 out of 75 control subjects yielded negative SPT results.
- Eight of 37 relatives tested positive, all being parents of CF patients.
Conclusions:
- The sweat patch test (SPT) demonstrates high reliability and accuracy for cystic fibrosis detection.
- SPT is a valuable, portable, and simple screening tool for cystic fibrosis when sufficient sweat is produced.