[Clofibrate and phosphate metabolism]

Experiments on rabbits with clofibrate and phosphate added to cholesterol-rich (2%) diet showed similar effects of both substances. During the first month of the experiment, total plasma lipid and total cholesterol level remained within normal range, thereafter up to the third month their level increased. The phosphataemia and phosphaturia showed similar dynamics. The results suggest a similar mechanism of action of both studied substances.