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Diffusion of ciprofloxacin into prostatic fluid.

A Dalhoff, W Weidner

European Journal of Clinical Microbiology

|August 1, 1984

Summary

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Ciprofloxacin effectively penetrates prostatic fluid, showing higher concentrations than in serum over time. This suggests potential efficacy for treating chronic bacterial prostatitis.

Area of Science:

Pharmacology
Urology

Background:

Chronic bacterial prostatitis requires effective antibiotic penetration into prostatic tissues.
Understanding drug distribution in prostatic fluid is crucial for treatment efficacy.

Purpose of the Study:

To assess the diffusion of ciprofloxacin into prostatic fluid.
To evaluate ciprofloxacin's potential therapeutic role in chronic bacterial prostatitis.

Main Methods:

Ten healthy volunteers received a 500 mg dose of ciprofloxacin.
Ciprofloxacin concentrations were measured in serum and seminal fluid using agar diffusion and bioassay.
Split ejaculates and expressed prostatic secretions were analyzed.

Main Results:

Initially, serum levels were double seminal fluid levels.

Related Experiment Videos

After 12 and 24 hours, seminal fluid concentrations were tenfold higher than serum levels.

Prostatic secretion concentrations ranged from 0.9 to 15 mg/l, indicating significant diffusion.

Conclusions:

Ciprofloxacin demonstrates pronounced diffusion into prostatic fluid.
The drug's pharmacokinetic profile supports its potential efficacy in treating chronic bacterial prostatitis.