[Leu5]enkephalin inhibits norepinephrine-induced contraction of rat aorta

Leucine-enkephalin produces a dose related decrease in the contractile response of spirally cut strips of rat aorta to norepinephrine (NE). The maximal effect (55.0 +/- 1.0 percent reduction in developed tension) occurs at a leucine-enkephalin concentration of 10(-10) M. The attenuation of contractile response is reversed by naloxone.