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The effects of linked loci on estimates of relative viability derived from pedigree analysis
Abstract:
The effect of viability selection at linked loci on segregation ratios at a specified studied locus is analysed in this paper for the crosses of a heterozygote to a homozygote and of two heterozygotes. Both autosomal and sex-linked loci are treated. The analysis indicates that it would be unusual for the change in frequency of a given allele at the studied locus to be distorted by as much as one per cent by the combined effects (assumed to be additive) of selection at all linked loci. This result encourages the use of pedigree analysis in tests of the null hypothesis of selective neutrality of the genotypes at a particular locus since the inevitable cases where selection at linked loci does lead to incorrect rejection of the null hypothesis should be relatively few.
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Lucien Cuénot discovered lethal alleles in 1905 while studying the inheritance of coat color in mice. The agouti gene is responsible for the color of the coat in mice. This gene codes for an agouti-signaling protein, which is responsible for melanin distribution in mammals. The wild-type allele gives rise to gray-brown coat color in mice, while the mutant allele gives rise to yellow coat color. In addition to coat color, the agouti gene is associated with the yellow...

