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Related Experiment Videos

Plasma progesterone concentrations and infant temperament.

M Weissbluth, O C Green

    Journal of Developmental and Behavioral Pediatrics : JDBP
    |October 1, 1984
    PubMed
    Summary

    Progesterone, a central nervous system depressor, was studied in 42 infants. Higher progesterone levels correlated with less intense infant temperaments, suggesting a potential behavioral depressor effect.

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    Area of Science:

    • Neuroscience
    • Developmental Psychology
    • Endocrinology

    Background:

    • Progesterone and its metabolites are known central nervous system (CNS) depressors.
    • Understanding early-life hormonal influences on infant behavior is crucial for developmental research.

    Purpose of the Study:

    • To investigate the relationship between plasma progesterone concentrations and infant temperament.
    • To explore the potential depressor effects of progesterone on infant behavior.

    Main Methods:

    • Assessed plasma progesterone concentrations in 42 normal infants (median age 36 days).
    • Correlated progesterone levels with temperament ratings, specifically approach/withdrawal and intensity.
    • Compared progesterone levels between "easier" and "more difficult" infants.

    Main Results:

    • Plasma progesterone concentrations showed significant negative correlations with approach/withdrawal (r = -0.35, p = 0.01) and intensity (r = -0.28, p = 0.04).
    • Infants with "easier" temperaments tended to have higher plasma progesterone concentrations (25 ± 4 ng/dl) compared to "more difficult" infants (17 ± 3 ng/dl), though this difference was not statistically significant (p = 0.15).

    Conclusions:

    • The findings support the hypothesis that progesterone or its metabolites may exert a behavioral depressor effect in infancy.
    • Progesterone's influence on CNS activity may contribute to observable differences in infant temperament and behavior.

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