Theoretical model of gastrointestinal absorption of lead

A theoretical model is presented which is used to explain gastrointestinal absorption of ingested lead from use of traditional medicines. Dissolution processes are discussed and the relative contributions of pore and passive diffusion through the intestinal epithelium for the resulting species examined. The determination of the rate of absorption is described in terms of a mathematical three-compartment system and effects of particle size are considered by reference to the Noyes-Whitney dissolution rate law.