Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Why do melanomas ulcerate?

J M Mascaro, J Castro, T Castel

    Journal of Cutaneous Pathology
    |August 1, 1984
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Antimicrobial resistance patterns of Staphylococcus spp. isolated from clinical specimens of companion animals in Northern Portugal, 2021-2023.

    Veterinary journal (London, England : 1997)·2024
    Same author

    Exploring the prevalence and antibiotic resistance profile of Klebsiella pneumoniae and Klebsiella oxytoca isolated from clinically ill companion animals from North of Portugal.

    Research in veterinary science·2023
    Same author

    Applying genomic approaches to delineate conservation strategies using the freshwater mussel Margaritifera margaritifera in the Iberian Peninsula as a model.

    Scientific reports·2022
    Same author

    The impacts of seasonal variation and climate on food utilization in a population of critically endangered cotton-top tamarins (Saguinus oedipus) in Colombia: A 22-year longitudinal study.

    American journal of primatology·2022
    Same author

    Influence of cavitation, pelleting, extrusion and torrefaction petreatments on anaerobic biodegradability of barley straw and vine shoots.

    Chemosphere·2021
    Same author

    Letter to the Editor: A response to 'What is lameness and what (or who) is the gold standard to detect it?'

    Equine veterinary journal·2018
    Same journal

    Blastic Plasmacytoid Dendritic Cell Neoplasm.

    Journal of cutaneous pathology·2026
    Same journal

    Atypical Grover Disease Associated With Merkel Cell Carcinoma: A Novel Paraneoplastic Presentation.

    Journal of cutaneous pathology·2026
    Same journal

    Profile of a Founder: Herbert Zachareus Lund.

    Journal of cutaneous pathology·2026
    Same journal

    The National Resident Match Program Arrives in Dermatopathology: 15 Years of Resilient Advocacy by the American Society of Dermatopathology's Fellowship Training Program Directors' Committee.

    Journal of cutaneous pathology·2026
    Same journal

    Evaluating Large Language Models for Melanocytic Lesion Pathology Report Interpretation.

    Journal of cutaneous pathology·2026
    Same journal

    An Atypical Skin Presentation of Adult-Onset Still's Disease With Histological Description: A Case Report.

    Journal of cutaneous pathology·2026
    See all related articles

    Ulceration in malignant melanoma (MM) correlates with higher mitotic activity. This suggests proliferating tumor cells or tumor expansion may cause ulceration, impacting prognosis.

    Area of Science:

    • Oncology
    • Dermatology
    • Pathology

    Background:

    • Ulceration is a known negative prognostic indicator in malignant melanoma (MM).
    • The underlying mechanisms driving melanoma ulceration remain incompletely understood.

    Purpose of the Study:

    • To investigate the potential causes of ulceration in malignant melanoma.
    • To explore the relationship between melanoma ulceration and mitotic index.

    Main Methods:

    • Comparative analysis of 69 ulcerated and 69 non-ulcerated malignant melanomas.
    • Quantification of mitotic figures per 10 high-power fields in tumor samples.

    Main Results:

    • A statistically significant correlation (P < 0.001) was observed between melanoma ulceration and a higher mitotic index.

    Related Experiment Videos

  • Ulcerated melanomas predominantly exhibited a high mitotic count (≥7 figures/10 HPF).

    • Conclusions:

    • Melanoma ulceration is likely caused by epidermal destruction from rapidly proliferating neoplastic cells.
    • Tumor expansile activity altering blood supply may also contribute to ulceration.
    • The strong association between ulceration and mitotic activity clarifies its prognostic significance.