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Peripheral nerve morphometry in stroke patients.

M Pollock, H Nukada, S Allpress

    Journal of the Neurological Sciences
    |September 1, 1984
    PubMed
    Summary
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    Stroke can cause peripheral nerve damage, leading to atrophy and demyelination in affected limbs. This study reveals significant nerve fiber abnormalities in stroke survivors, impacting nerve health.

    Area of Science:

    • Neuroscience
    • Neurology
    • Peripheral Nerve Disorders

    Background:

    • Stroke, a cerebral lesion, can affect motor function and potentially impact peripheral nerves.
    • Peripheral nerve integrity is crucial for motor control and sensation, but its post-stroke status is not fully understood.

    Purpose of the Study:

    • To investigate morphometric changes in sural nerve biopsies from stroke patients.
    • To identify abnormalities in peripheral nerves of affected and non-affected limbs in hemiparetic and hemiplegic individuals.

    Main Methods:

    • Morphometric examination of sural nerve biopsy specimens.
    • Comparison between affected and non-affected limbs in stroke patients.

    Main Results:

    • Increased frequency of abnormal teased nerve fibers with clustered internodes and reduced myelin thickness (≥50%).

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  • Reduced mean diameter of myelinated nerve fibers in affected limbs.
  • Evidence suggests primary peripheral nerve atrophy with secondary demyelination.

    • Conclusions:

    • Cerebral lesions, such as stroke, frequently compromise peripheral nerve structural integrity.
    • Potential etiological factors include disuse, transynaptic degeneration, ischemia, pressure, and reduced axoplasmic flow.
    • Peripheral nerve atrophy and demyelination are significant findings in stroke survivors' affected limbs.