Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Break points in human chromosomes.

C W Yu, D S Borgaonkar, D R Bolling

    Human Heredity
    |January 1, 1978
    PubMed
    Summary
    This summary is machine-generated.

    Human chromosome breaks in structural rearrangements are non-random, with higher frequencies in negative band areas and specific chromosomal regions. This analysis reveals distinct patterns in break point distribution across the genome.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    [Clinical phenotypic and genotypic analysis of 5 pediatric patients with β-ketothiolase deficiency].

    Zhonghua er ke za zhi = Chinese journal of pediatrics·2023
    Same author

    [<i>BCS1</i>Neonatal growth retardation and lactic acidosis initiated by novel mutation sites in <i>L</i> gene].

    Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine]·2023
    Same author

    Formula-feeding and the risk of type-2 diabetes mellitus among Hong Kong adolescents.

    Hong Kong medical journal = Xianggang yi xue za zhi·2018
    Same author

    Thigh muscle volume predicted by anthropometric measurements and correlated with physical function in the older adults.

    The journal of nutrition, health & aging·2011
    Same author

    Unusual manifestations of vertebral osteomyelitis: intraosseous lesions mimicking metastases.

    AJNR. American journal of neuroradiology·2008
    Same author

    Childhood obesity, gender, actual-ideal body image discrepancies, and physical self-concept in Hong Kong children: cultural differences in the value of moderation.

    Developmental psychology·2007
    Same journal

    Comparative profiles of pediatric Mendeliome: A Single-Centre 572-Whole-Exome Sequencing Study in Xinjiang.

    Human heredity·2026
    Same journal

    Erratum.

    Human heredity·2026
    Same journal

    Exploratory Analysis of HMGB1 Genetic Variants and Their Potential Association with Lung Cancer Susceptibility and Chemotherapy Response in a Chinese Population.

    Human heredity·2025
    Same journal

    Weighted Burden Analysis of Rare Genetic Variants Identifies Novel Genes with Effects on BMI.

    Human heredity·2025
    Same journal

    Generalized Stable Population and Agent-Based Models of Phenotypic Transmission in Human Populations, with an Application to Body Size.

    Human heredity·2025
    Same journal

    Proteinase-activated receptor 2 (PAR-2) expression and F2RL1 genetic variants are associated with asthma: a case-control study in the Chinese population.

    Human heredity·2025
    See all related articles

    Area of Science:

    • Human Genetics
    • Cytogenetics
    • Genomics

    Background:

    • Structural rearrangements in human chromosomes are identifiable via banding techniques.
    • Understanding spontaneous break point distribution is crucial for genomic stability research.

    Purpose of the Study:

    • To analyze the randomness and distribution of spontaneous break points in the human genome.
    • To identify specific chromosomal regions with non-random break point occurrences.

    Main Methods:

    • Analysis of reported chromosomal break points from published sources up to October 1976.
    • Application of chi-squared tests to assess the randomness of break point distribution.
    • Comparison of break point frequency relative to chromosome length and band type.

    Related Experiment Videos

    Main Results:

    • Chromosome breakage is highly non-random, favoring negative band areas, centromeric, and terminal regions.
    • Break distribution is not proportional to chromosome length; shorter chromosomes exhibit more breaks per unit length, with exceptions.
    • Chromosomes 9, 13, 18, 21, 22, and Y show the highest breaks per unit length, while 16, 6, 2, 3, and 19 show the fewest.
    • Specific bands like 18p11, 21q22, and Yp11 are hotspots for breaks; 53 bands had no reported breaks.

    Conclusions:

    • Human chromosome break points exhibit non-random distribution patterns.
    • Specific genomic regions and chromosome lengths are associated with differential break frequencies.
    • Findings contribute to understanding the mechanisms underlying structural chromosomal rearrangements.