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Solid-solid reaction between sulfacetamide and phthalic anhydride.

H L Weng, E L Parrott

    Journal of Pharmaceutical Sciences
    |August 1, 1984
    PubMed
    Summary
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    This study presents thermal and kinetic data for the solid-state reaction between sulfacetamide and phthalic anhydride. Pharmaceutical parameters like pressure and particle size were investigated to understand their impact on reaction speed.

    Area of Science:

    • Solid-state chemistry
    • Pharmaceutical sciences
    • Reaction kinetics

    Background:

    • Sulfacetamide and phthalic anhydride are key pharmaceutical compounds.
    • Solid-state reactions are crucial in drug formulation and manufacturing.
    • Understanding reaction kinetics is vital for optimizing pharmaceutical processes.

    Purpose of the Study:

    • To present thermal and kinetic data for the solid-state addition reaction of sulfacetamide and phthalic anhydride.
    • To investigate the influence of pharmaceutical parameters on reaction kinetics.
    • To analyze the impact of compressional pressure, particle size, concentration, and temperature on solid-state reaction rates.

    Main Methods:

    • Solid-state addition reaction analysis.
    • Compaction method for sample preparation.

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  • Thermal analysis (e.g., DSC, TGA).
  • Kinetic modeling of reaction data.

    • Main Results:

    • Detailed thermal and kinetic data were obtained for the reaction.
    • Compressional pressure, particle size, concentration, and temperature significantly influenced reaction kinetics.
    • Specific relationships between parameters and reaction rates were quantified.

    Conclusions:

    • The study provides valuable data on the solid-state reaction kinetics of sulfacetamide and phthalic anhydride.
    • Pharmaceutical parameters demonstrably affect solid-state reaction rates, offering insights for formulation design.
    • The findings can aid in optimizing manufacturing processes for pharmaceuticals involving these compounds.