Malignant change in a verrucous nevus.

Area of Science:

• Dermatology
• Oncology
• Pathology

Background:

• Verrucous nevi are benign congenital skin growths.
• Malignant transformation within verrucous nevi is exceptionally uncommon.
• Linear distribution suggests a developmental anomaly.

Observation:

• A 41-year-old male presented with a long-standing verrucous nevus.
• The nevus exhibited a linear distribution.
• Histopathological examination revealed squamous-cell carcinoma.

Findings:

• The study reports a rare instance of squamous-cell carcinoma arising within a verrucous nevus.
• This malignant change occurred in a nevus with a linear pattern.
• The rarity of such cases is noted, with few reported in medical literature.

Implications:

• This case underscores the importance of vigilant monitoring for verrucous nevi, especially those with long duration and linear distribution.
• It contributes to the understanding of rare oncogenic pathways in dermatological conditions.
• Further research may explore risk factors and diagnostic markers for malignant transformation in verrucous nevi.