Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

An immune response profile model for immunogenicity quantitation.

S J Smith, D N Lawrence, G R Noble

    Journal of Theoretical Biology
    |September 7, 1984
    PubMed
    Summary

    We developed an Immune Response (IR) profile model to predict vaccine immunogenicity and antibody titers. This model offers a universal method for assessing vaccine effectiveness across different conditions.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    AIDS-specific screening and therapy still elusive.

    Immunology today·2014
    Same author

    Long-term safety analysis of preventive HIV-1 vaccines evaluated in AIDS vaccine evaluation group NIAID-sponsored Phase I and II clinical trials.

    Vaccine·2003
    Same author

    A survey of Australasian obstetric anaesthesia audit.

    Anaesthesia and intensive care·1999
    Same author

    Common conformational effects in the p53 protein of vinyl chloride-induced mutations.

    Journal of protein chemistry·1999
    Same author

    Comparison of plasma total homocysteine measurements in 14 laboratories: an international study.

    Clinical chemistry·1999
    Same author

    Validation of accuracy-based amino acid reference materials in dried-blood spots by tandem mass spectrometry for newborn screening assays.

    Clinical chemistry·1999

    Area of Science:

    • Immunology
    • Vaccinology
    • Mathematical Modeling

    Background:

    • Assessing vaccine immunogenicity is complex, influenced by dose, timing, and vaccine type.
    • Existing models often lack the ability to universally predict serological responses.
    • Understanding immune response dynamics is crucial for vaccine development and efficacy evaluation.

    Purpose of the Study:

    • To propose a novel analytical model, the Immune Response (IR) profile, for characterizing vaccine immunogenicity.
    • To establish a mathematical relationship between pre- and post-vaccination antibody titers.
    • To predict maximal antibody titers and cohort geometric mean titers irrespective of vaccine specifics.

    Main Methods:

    • Development of an analytical model (IR profile) based on pre- and post-vaccination antibody titers.
    • Analysis of booster vaccine responses in seropositive subjects.
    • Application of the model to influenza, malaria, diphtheria, and rubella data.

    Main Results:

    • The IR profile model mathematically relates pre- and post-vaccination titers.
    • Maximal serological response capability is determinable regardless of vaccine dose, interval, or state (live/killed).
    • The model accurately predicts antibody titers for primary immunization cohorts and booster responses.

    Conclusions:

    • The IR profile model provides a unified framework for understanding vaccine immunogenicity.
    • It allows prediction of key serological response parameters.
    • The model's applicability extends beyond influenza vaccines to natural infections and other vaccine types, suggesting broader immunoregulation insights.

    Related Experiment Videos