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Quantitative genetics and developmental constraints on evolution by selection.

J M Cheverud

    Journal of Theoretical Biology
    |September 21, 1984
    PubMed
    Summary
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    Microevolutionary theory, using the genetic variance/covariance matrix, accounts for developmental constraints. This matrix captures internal selection and non-random mutation, influencing evolutionary trajectories beyond simple random mutation and selection.

    Area of Science:

    • Evolutionary biology
    • Quantitative genetics
    • Developmental biology

    Background:

    • Macroevolutionary phenomena like morphological novelty and evolutionary directionality challenge purely random mutation and selection principles.
    • A potential third principle, epigenetic in nature, is proposed to be missing from current microevolutionary theory.
    • This third principle has been linked to internal selection and non-random phenotypic effects of mutation.

    Purpose of the Study:

    • To demonstrate that the genetic variance/covariance matrix in quantitative genetics inherently measures developmental constraints.
    • To show how these constraints arise from internal selection and non-random mutation.
    • To integrate these concepts within microevolutionary theory.

    Main Methods:

    • Analysis of the genetic variance/covariance matrix within quantitative genetic theory.

    Related Experiment Videos

  • Examination of how this matrix influences the response to selection compared to the selection gradient.
  • Discussion of theories predicting genetic variance/covariance patterns under stabilizing selection and mutation.

    • Main Results:

    • The genetic variance/covariance matrix quantifies developmental constraints stemming from internal selection and non-random mutation.
    • This matrix causes evolutionary responses to deviate from optimal predictions based on direct phenotypic selection.
    • Microevolutionary theory, via the genetic variance/covariance matrix, incorporates developmental constraints on natural selection.

    Conclusions:

    • Microevolutionary theory adequately accounts for developmental constraints influencing evolutionary patterns.
    • The genetic variance/covariance matrix is a key component for understanding these constraints.
    • Further research can explore predicting genetic variance/covariance patterns from selection and mutation effects.