Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Toxicological screening.

G Zbinden, J Elsner, U A Boelsterli

    Regulatory Toxicology and Pharmacology : RTP
    |September 1, 1984
    PubMed
    Summary
    This summary is machine-generated.

    Toxicological screening tests use simple methods to detect chemical toxicity in animals. These validated tests help prioritize chemical safety evaluations and identify promising candidates for further research.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Differential cytotoxic, growth-inhibiting and lipid-peroxidative activities of four different asbestos fibres in vitro.

    Toxicology in vitro : an international journal published in association with BIBRA·2010
    Same author

    Neurotoxic effects of bismuth in vitro.

    Toxicology in vitro : an international journal published in association with BIBRA·2010
    Same author

    Concluding remarks.

    Toxicology in vitro : an international journal published in association with BIBRA·2010
    Same author

    Psychotropic drugs as inhibitors of glycerolipid biosynthesis and secretion in primary rat hepatocyte cultures.

    Toxicology in vitro : an international journal published in association with BIBRA·2010
    Same author

    n-Nonanoyl-CCL14 (NNY-CCL14), a novel inhibitor of allergic airway inflammation is a partial agonist of human CCR2.

    Allergy·2008
    Same author

    Effect of steady torque twisting on the orientation of cortical microtubules in the epidermis of the sunflower hypocotyl.

    Plant biology (Stuttgart, Germany)·2008
    Same journal

    The NTP Chronic Inhalation Study Does Not Support an Inherent Lung Cancer Hazard of Talc: Implications of Lung Particle Overload and Maximum Tolerated Dose.

    Regulatory toxicology and pharmacology : RTP·2026
    Same journal

    Consideration of Carcinogenicity and Mode of Action Information by an Independent Expert Panel to Support Derivation of No-Significant-Risk-Level Values for Vinyl Acetate Monomer.

    Regulatory toxicology and pharmacology : RTP·2026
    Same journal

    Which carcinogenicity study should I use? Automated identification of reliable studies.

    Regulatory toxicology and pharmacology : RTP·2026
    Same journal

    Adoption of artificial intelligence in drug review across the lifecycle: Transformation of regulatory decision-making.

    Regulatory toxicology and pharmacology : RTP·2026
    Same journal

    Cardiovascular outcomes following intrauterine and lactational exposure to cyantraniliprole in male Wistar rats.

    Regulatory toxicology and pharmacology : RTP·2026
    Same journal

    Pesticide residue and mycotoxin occurrence in apples and their impact on human health in Morocco.

    Regulatory toxicology and pharmacology : RTP·2026
    See all related articles

    Area of Science:

    • Toxicology
    • Chemical Safety
    • In vivo testing

    Background:

    • Dose- and time-related toxic effects of chemicals can be identified using simple animal tests.
    • Developing effective toxicological screening strategies is crucial for chemical safety assessment.

    Purpose of the Study:

    • To discuss strategies for establishing reliable toxicological screening tests.
    • To outline key steps including target definition, method selection, and criterion setting.
    • To present an example of screening for hemolytic effects.

    Main Methods:

    • Defining specific toxicological targets and selecting appropriate testing methods.
    • Establishing clear test criteria and validating them with standard reference chemicals.
    • Utilizing biostatistics for comparing results between treated animals and controls or using preset criteria.

    Related Experiment Videos

    Main Results:

    • Screening tests provide a flexible approach to evaluating chemical toxicity.
    • Validation ensures consistent detection of reference standards.
    • Evaluation can be performed through comparative biostatistics or preset criteria.

    Conclusions:

    • Toxicological screening tests do not replace comprehensive safety studies but aid in prioritizing chemicals.
    • These methods help identify promising candidates within chemical series for further investigation.
    • Screening tests are valuable tools for efficient chemical safety assessment.