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Sustained-release anhydrous theophylline in preventing exercise-induced asthma
Respiration; International Review of Thoracic Diseases
|January 1, 1984
Summary
Sustained-release theophylline effectively prevented exercise-induced asthma (EIA) in patients. This study highlights theophylline
Area of Science:
- Pulmonology
- Pharmacology
Background:
- Exercise-induced asthma (EIA) is a significant concern for asthmatic patients.
- EIA can serve as a model for studying bronchodilating agents.
Purpose of the Study:
- To evaluate the efficacy of a sustained-release theophylline preparation in preventing EIA.
- To compare theophylline's protective effects against placebo in a double-blind, cross-over study.
Main Methods:
- 15 EIA-positive asthmatic patients participated in a double-blind, cross-over study.
- Patients underwent four free running tests with prior administration of theophylline or placebo.
- Lung function parameters (FEV1.0, FEF50, FEF25, sGaw) were measured post-exercise.
Main Results:
- Theophylline plasma levels were satisfactory (7-9 µg/ml) between 6 and 12 hours post-administration.
- A significant protective effect against exercise-induced bronchoconstriction was observed with theophylline compared to placebo.
- This protective effect was noted across most lung function parameters, excluding the initial test where absorption was insufficient.
Conclusions:
- Sustained-release theophylline demonstrates significant efficacy in preventing exercise-induced asthma.
- Theophylline offers a promising therapeutic option for EIA, potentially superior to other drug classes.
- This finding adds to the known benefits of theophylline, enhancing its therapeutic profile.
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