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Related Experiment Videos

Analysis of cerebrospinal fluid specific gravity.

J W Wilson, J B Stevens

    Journal of the American Veterinary Medical Association
    |April 15, 1978
    PubMed
    Summary
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    Cerebrospinal fluid (CSF) specific gravity in normal dogs is typically 1.004-1.006. Most dogs with neurologic disease did not show elevated CSF specific gravity, suggesting limited diagnostic value.

    Area of Science:

    • Veterinary Neurology
    • Clinical Pathology

    Background:

    • Cerebrospinal fluid (CSF) analysis is crucial for diagnosing canine neurologic diseases.
    • Specific gravity is a basic parameter of CSF, but its diagnostic utility in veterinary neurology is not well-established.

    Purpose of the Study:

    • To determine the reference range for specific gravity in clinically normal dogs' CSF.
    • To evaluate the diagnostic or prognostic value of CSF specific gravity in dogs with suspected neurologic disease.

    Main Methods:

    • Retrospective analysis of 124 CSF samples from dogs with suspected neurologic disease.
    • Comparison of CSF specific gravity values between normal dogs and those with neurologic conditions.
    • Measurement of CSF specific gravity using a refractometer.

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    Main Results:

    • The specific gravity of CSF in 71 clinically normal dogs ranged from 1.004 to 1.006 (mean 1.005).
    • In a cohort of 124 dogs with suspected neurologic disease, only 24.2% (30 samples) had a CSF specific gravity greater than 1.006.
    • No significant diagnostic or prognostic value was identified for CSF specific gravity determination.

    Conclusions:

    • The established reference range for canine CSF specific gravity is 1.004-1.006.
    • Elevated CSF specific gravity is uncommon in dogs with neurologic disease, limiting its diagnostic utility.
    • Further research may be needed to explore other CSF parameters for improved diagnostic accuracy.