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Morphologic changes in annulus fibrosus during aging. An ultrastructural study in rats.

F Postacchini, M Bellocci, M Massobrio

    Spine
    |September 1, 1984
    PubMed
    Summary

    Aging significantly alters the annulus fibrosus in rats, with changes in cell morphology, collagen fiber diameter, and extracellular matrix composition observed from newborn to old age.

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    Area of Science:

    • Biomedical Engineering
    • Connective Tissue Biology
    • Aging Research

    Background:

    • The annulus fibrosus is a critical component of the intervertebral disc, providing structural integrity.
    • Understanding age-related changes in the annulus fibrosus is essential for addressing disc degeneration.

    Purpose of the Study:

    • To investigate the morphologic changes in the annulus fibrosus of rats at different life stages (newborn, young, old).
    • To characterize the cellular and extracellular matrix alterations associated with aging in this tissue.

    Main Methods:

    • Morphologic examination of annulus fibrosus tissue from rats of varying ages.
    • Microscopic analysis focusing on cellular features, collagen fiber arrangement and diameter, and proteoglycan and elastic fiber presence.

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    Main Results:

    • Newborn annulus fibrosus shows distinct inner, middle, and outer portions with specific cell types and collagen orientations.
    • Young annulus fibrosus develops a transition and lamellar zone with cells exhibiting intermediate chondrocyte-fibroblast features and larger collagen fibers.
    • Old annulus fibrosus exhibits an enlarged transition zone, reduced cell numbers, and sparse ergastoplasm, indicating cellular senescence.

    Conclusions:

    • Aging induces significant morphologic and compositional changes in the rat annulus fibrosus.
    • These age-related alterations, including changes in collagen and cellularity, may contribute to intervertebral disc dysfunction.