Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Pyrethroid-mediated skin sensory stimulation characterized by a new behavioral paradigm.

S Z Cagen, L A Malley, C M Parker

    Toxicology and Applied Pharmacology
    |November 1, 1984
    PubMed
    Summary

    Pyrethroid exposure causes skin tingling without visible irritation. A new animal model quantifies this sensory effect, aiding in the evaluation of pyrethroid-induced skin stimulation.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Evaluation of reproductive/developmental and repeated dose (subchronic) toxicity and cytogenetic effects in rats of a roofing asphalt fume condensate by nose-only inhalation.

    Regulatory toxicology and pharmacology : RTP·2011
    Same author

    Oral toxicity study of 2-pentenenitrile in rats with reproductive toxicity screening test.

    Drug and chemical toxicology·2006
    Same author

    Reproductive and developmental toxicity of inhaled 2,3-dichloro-1,3-butadiene in rats.

    Reproductive toxicology (Elmsford, N.Y.)·2006
    Same author

    COPD exacerbations . 3: Pathophysiology.

    Thorax·2006
    Same author

    Physiological changes during symptom recovery from moderate exacerbations of COPD.

    The European respiratory journal·2005
    Same author

    Inhalation toxicity of methylglutaronitrile in rats.

    Drug and chemical toxicology·2003

    Area of Science:

    • Toxicology
    • Dermatology
    • Animal Models

    Background:

    • Occupational pyrethroid exposure is linked to skin sensory effects like itching and tingling.
    • These effects occur without visible skin irritation and are not detected by standard Draize tests.

    Purpose of the Study:

    • To develop and validate a quantitative animal model for studying pyrethroid-induced non-erythematous skin sensory stimulation.

    Main Methods:

    • Guinea pigs were treated with pyrethroids on one side of their shaved back and controls on the other.
    • Behavioral responses (licking, rubbing, scratching, biting) were quantified.
    • A chemical irritant (oil of mustard) was used to assess residual stimulation.

    Main Results:

    Related Experiment Videos

  • Animals showed significantly more behavioral responses to pyrethroids than controls.
  • The sensory response peaked within the first hour and subsided by the fourth hour.
  • Cyano-containing pyrethroids induced greater sensory stimulation than non-cyano pyrethroids.

    • Conclusions:

    • The developed animal model effectively quantifies pyrethroid-induced skin sensory stimulation.
    • This model differentiates sensory effects from visible skin irritation.
    • It provides a tool for evaluating the sensory properties of pyrethroids.