[The effect of growth marker proteins on the ionic permeability of rabbit liver mitochondria]

The growth marker proteins from blood serum of new-born rabbits and G-myeloma-bearing people were studied for their effect on ionic permeability of rabbit liver mitochondria. The proteins under study induce an increase in nonspecific ionic permeability and swelling of mitochondria. Thiol compounds, in particular CoA8H (in small concentrations) neutralize the effect of growth marker proteins on the bioenergetic characteristics of mitochondria and lower considerably the protein-induced nonspecific ionic permeability.