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[Interaction of isoxicam and digoxin].
Zeitschrift Fur Rheumatologie
|July 1, 1984
Summary
Isoxicam maintenance therapy did not significantly alter digoxin plasma levels in healthy volunteers. No toxic digoxin concentrations or adverse renal effects were observed during this drug interaction study.
Area of Science:
- Pharmacology
- Clinical Pharmacy
- Drug Interactions
Context:
- Digoxin is a cardiac glycoside used to treat heart failure and arrhythmias.
- Isoxicam is a non-steroidal anti-inflammatory drug (NSAID) used for its anti-inflammatory and analgesic properties.
- Understanding potential drug interactions is crucial for patient safety and effective therapeutic outcomes.
Purpose:
- To investigate the effect of Isoxicam maintenance therapy on steady-state plasma levels of digoxin.
- To assess the safety profile of concomitant Isoxicam and digoxin administration.
- To evaluate changes in renal function and clinicochemical parameters during the study.
Summary:
- A study involving 12 healthy volunteers examined the impact of daily Isoxicam (200 mg) on digoxin plasma levels.
- One participant withdrew due to cardiac sensations after digoxin loading.
- No statistically significant differences in digoxin levels were observed during or after Isoxicam treatment, and no toxic concentrations or adverse renal effects were noted.
Impact:
- This study suggests that Isoxicam, at the studied dosage, does not significantly affect digoxin pharmacokinetics in healthy individuals.
- The findings contribute to the understanding of NSAID-drug interactions, specifically with cardiac glycosides.
- Results indicate a potentially safe co-administration profile regarding digoxin levels and renal function, warranting further clinical investigation.