Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Circulatory and EEG changes during resuscitation in experiments.

G Temes, J Lantos, B Török

    Acta Physiologica Hungarica
    |January 1, 1984
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Prognostic neurodevelopmental testing of preterm infants: do we need to change the paradigm?

    Journal of perinatology : official journal of the California Perinatal Association·2017
    Same author

    l-Arginine Pathway Metabolites Predict Need for Intra-operative Shunt During Carotid Endarterectomy.

    European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery·2016
    Same author

    Does diagnosis influence end-of-life decisions in the neonatal intensive care unit?

    Journal of perinatology : official journal of the California Perinatal Association·2014
    Same author

    Have the boundaries of the 'grey zone' of perinatal resuscitation changed for extremely preterm infants over 20 years?

    Acta paediatrica (Oslo, Norway : 1992)·2012
    Same author

    End of life, death and dying in neonatal intensive care units in Latin America.

    Acta paediatrica (Oslo, Norway : 1992)·2012
    Same author

    Ischaemic postconditioning reduces serum and tubular TNF-α expression in ischaemic-reperfused kidney in healthy rats.

    Clinical hemorheology and microcirculation·2012

    Direct heart massage with oxygen ventilation offers the highest success rate for canine resuscitation, achieving critical blood pressure and flow targets. Brain oxygen levels indicate prognosis, with surface oxygen increases preceding EEG normalization.

    Area of Science:

    • Cardiology
    • Neurology
    • Critical Care Medicine

    Background:

    • Ventricular fibrillation necessitates immediate resuscitation efforts.
    • Optimizing blood flow and oxygenation during cardiopulmonary resuscitation (CPR) is crucial for patient survival.
    • The effectiveness of different CPR techniques and ventilation strategies requires further investigation.

    Purpose of the Study:

    • To compare the efficacy of direct versus external thoracic heart massage combined with oxygen or room air ventilation in anesthetized dogs.
    • To determine the physiological parameters and minimal requirements for successful resuscitation.
    • To assess the correlation between brain surface oxygenation and neurological recovery during resuscitation.

    Main Methods:

    • Measurements of blood pressure (BP), carotid artery flow (CAF), arterial oxygen tension (paO2), and brain surface oxygen tension (bs-pO2) were recorded in dogs.

    Related Experiment Videos

  • Electrocardiogram (ECG) and electroencephalogram (EEG) were monitored throughout the experiment.
  • Ventricular fibrillation was induced, followed by interventions including external and direct heart massage with either oxygen or room air ventilation, and defibrillation.

    • Main Results:

    • Successful resuscitation rates were highest with direct heart massage and oxygen ventilation (88%), followed by external thoracic massage with oxygen (76%) and external massage with room air (68%).
    • Direct heart massage yielded the highest BP and CAF, with minimal requirements of 5 kPa (40 mmHg) BP and 13 ml/min CAF for success.
    • Oxygen ventilation normalized brain surface pO2, while room air resulted in moderate increases; lack of bs-pO2 elevation indicated poor prognosis.

    Conclusions:

    • Direct heart massage with oxygen ventilation is the most effective resuscitation strategy in this canine model.
    • Achieving adequate blood pressure and flow is critical for resuscitation success.
    • Brain surface oxygenation dynamics provide valuable prognostic information, with increases preceding EEG normalization.