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Glomerular filtration rate during lithium therapy. A longitudinal study.

S B Jensen, H Rickers

    Acta Psychiatrica Scandinavica
    |September 1, 1984
    PubMed
    Summary
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    Lithium treatment did not significantly alter glomerular filtration rate (GFR) in patients over 16.5 months. Further long-term studies are recommended to confirm these findings on kidney function.

    Area of Science:

    • Nephrology
    • Pharmacology
    • Internal Medicine

    Background:

    • Lithium is a common mood stabilizer used in treating bipolar disorder.
    • Potential renal side effects of lithium therapy necessitate careful monitoring of kidney function.

    Purpose of the Study:

    • To investigate the effect of lithium therapy on glomerular filtration rate (GFR).
    • To assess changes in renal function in patients undergoing lithium treatment.

    Main Methods:

    • Glomerular filtration rate (GFR) was measured in 13 patients before and after a mean of 16.5 months of lithium treatment.
    • Standard GFR (m/min/1.73 m2) and plasma creatinine levels were monitored.

    Main Results:

    • No significant change in GFR (ml/min) was observed (101.9 to 98.3).

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  • Standard-GFR showed a significant decrease (88.4 to 84.8, P < 0.05), primarily due to increased body weight and surface area.
  • Plasma creatinine levels remained unchanged.

    • Conclusions:

    • Lithium therapy for a mean of 16.5 months does not appear to significantly affect glomerular filtration rate.
    • Longer-term observations using reliable GFR measurement methods are needed to fully evaluate lithium's impact on renal function.