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Depression and ventricular enlargement.

S Shima, T Shikano, T Kitamura

    Acta Psychiatrica Scandinavica
    |September 1, 1984
    PubMed
    Summary
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    Depressed patients often have an increased ventricular-brain ratio (VBR). This brain imaging marker is particularly pronounced in individuals with poor outcomes or specific clinical features.

    Area of Science:

    • Neuroimaging
    • Psychiatry
    • Brain Anatomy

    Background:

    • Depression is associated with various neurobiological changes.
    • Ventricular-brain ratio (VBR) is a measure of brain ventricle size, potentially reflecting brain atrophy.

    Purpose of the Study:

    • To investigate the relationship between depression and ventricular-brain ratio (VBR).
    • To identify clinical factors associated with elevated VBR in depressed patients.

    Main Methods:

    • Quantitative analysis of brain imaging data.
    • Comparison of VBR between depressed patients and control subjects.
    • Statistical analysis to correlate VBR with clinical characteristics.

    Main Results:

    • Depressed patients exhibited a significantly increased ventricular-brain ratio (VBR) compared to controls.

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  • Greater VBR was observed in patients with poor outcomes, single depressive episodes, onset at age 50 or older, and absence of melancholic features.

    • Conclusions:

    • Elevated VBR is a potential neuroimaging biomarker in depression.
    • Specific clinical profiles in depression may be linked to more pronounced ventricular enlargement.