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Ascorbic acid in thyroidectomized rats. I) Biosynthesis and catabolism.

N Nath, M Nath, M G Muddeshwar

    Acta Vitaminologica Et Enzymologica
    |January 1, 1984
    PubMed
    Summary
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    Thyroidectomy in rats altered ascorbic acid metabolism, increasing urinary excretion and liver enzyme activity. Thyroxine administration normalized these changes, suggesting a role in regulating vitamin C metabolism.

    Area of Science:

    • Biochemistry
    • Endocrinology
    • Nutritional Science

    Background:

    • Thyroid hormones play a crucial role in regulating various metabolic processes.
    • Ascorbic acid (vitamin C) is essential for numerous physiological functions.
    • The interplay between thyroid hormones and ascorbic acid metabolism is not fully understood.

    Purpose of the Study:

    • To investigate the impact of thyroidectomy on ascorbic acid metabolism in rats.
    • To determine the effect of thyroxine administration on these metabolic alterations.

    Main Methods:

    • Thyroidectomy was performed on rats.
    • Levels of ascorbic acid, dehydroascorbic acid, and diketogulonic acid were measured in liver, kidney, and urine.
    • Activities of ascorbic acid synthesizing and degrading enzymes were assessed.

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  • Thyroxine was administered daily or as a single dose to thyroidectomized rats.

    • Main Results:

    • Thyroidectomy led to decreased ascorbic acid and dehydroascorbic acid in liver and kidney, increased urinary total ascorbic acid, and decreased urinary glucuronic acid.
    • Activities of ascorbic acid degrading enzymes increased in the liver post-thyroidectomy.
    • Daily thyroxine administration for 10 days normalized liver enzyme activities, while a single dose did not.

    Conclusions:

    • Thyroidectomy significantly alters ascorbic acid metabolism in rats, affecting tissue levels and urinary excretion.
    • Thyroxine appears to play a role in regulating ascorbic acid metabolism, particularly through its effects on liver degrading enzymes.
    • Sustained thyroxine administration is necessary to restore normal ascorbic acid metabolism following thyroidectomy.