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Cefazolin concentrations in bone and synovial fluid.

D J Schurman, H P Hirshman, G Kajiyama

    The Journal of Bone and Joint Surgery. American Volume
    |April 1, 1978
    PubMed
    Summary

    Prophylactic cefazolin (one gram IV) in joint replacement surgery showed a serum half-life of 1.8 hours. Bone and synovial fluid concentrations were 5.7 µg/g and 24.4 µg/mL, respectively, during surgery.

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    Area of Science:

    • Pharmacology
    • Orthopedic Surgery
    • Infectious Disease

    Background:

    • Prophylactic antibiotics are crucial in preventing surgical site infections during orthopedic procedures.
    • Cefazolin is a commonly used cephalosporin antibiotic for surgical prophylaxis.

    Purpose of the Study:

    • To evaluate the pharmacokinetic profile of cefazolin in patients undergoing total joint replacement.
    • To determine cefazolin concentrations in bone and synovial fluid during surgery.

    Main Methods:

    • A single intravenous dose of one gram of cefazolin was administered to 48 patients.
    • Serum, bone, and synovial fluid samples were collected during surgery.
    • Antibiotic concentrations were measured using validated assays.

    Main Results:

    • The mean serum half-life of cefazolin was 1.8 hours, consistent with normal volunteers.
    • Mean bone concentration reached 5.7 µg/g.
    • Mean synovial fluid concentration was 24.4 µg/mL.

    Conclusions:

    • Single-dose intravenous cefazolin achieves adequate concentrations in serum, bone, and synovial fluid for prophylaxis in total joint replacement.
    • The pharmacokinetic profile in this patient group is similar to that in the general population.

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