Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Left ventricle-aortic coupling: prediction of contraction pattern.

H Piene, E S Myhre

    The American Journal of Physiology
    |October 1, 1984
    PubMed
    Summary

    This study models heart mechanics by linking ventricular diameter to volume changes and aortic impedance. The model accurately predicts key heart function metrics like pressure and flow, aiding cardiovascular research.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Postischemic mechanoenergetic inefficiency is related to contractile dysfunction and not altered metabolism.

    American journal of physiology. Heart and circulatory physiology·2001
    Same author

    [Hospital capacity and waiting time for treatment--is there a connection?].

    Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke·2000
    Same author

    [Hallway patients--a phenomenon possible to prevent?].

    Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke·2000
    Same author

    [Chronic heart failure--suggestion to a management program].

    Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke·1999
    Same author

    Left ventricular dysfunction following rewarming from experimental hypothermia.

    Journal of applied physiology (Bethesda, Md. : 1985)·1998
    Same author

    [Waiting lists and therapeutic guarantees--a wall of unwillingness?].

    Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke·1998

    Area of Science:

    • Cardiovascular Physiology
    • Biomedical Engineering
    • Computational Biology

    Background:

    • Understanding ventricular mechanics and afterload is crucial for diagnosing and treating heart conditions.
    • Previous models often simplified the complex interplay between ventricular performance and systemic load.

    Purpose of the Study:

    • To develop and validate a computational model predicting ventricular function under varying aortic impedance.
    • To establish a time-dependent pressure-diameter relationship for ventricular mechanical performance.

    Main Methods:

    • Established pressure-diameter and volume changes during systolic ejection in canine hearts.
    • Calculated aortic input impedance from aortic flow and pressure to represent ventricular afterload.
    • Developed a computational procedure integrating ventricular and load descriptions to predict cardiovascular variables.

    Main Results:

    • The model accurately predicted stroke volume, mean aortic pressure, and mean ventricular pressure across a range of aortic impedances.
    • Diameter shortening was predicted with less accuracy compared to pressure and flow metrics.
    • Incorporating ejection history improved flow pulse configuration prediction but not mean value accuracy.

    Conclusions:

    • The developed computational model provides a robust framework for predicting ventricular performance under altered loading conditions.
    • The model's accuracy in predicting key hemodynamic parameters highlights its potential for clinical and research applications in cardiology.

    Related Experiment Videos