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Decreased defibrillator-induced dysfunction with biphasic rectangular waveforms.

J L Jones, R E Jones

The American Journal of Physiology

|November 1, 1984

Summary

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Biphasic electrical waveforms improve cardiac cell recovery after defibrillation shocks. Specific waveform characteristics, like low-amplitude tails, significantly reduce postshock dysfunction and cell arrest time.

Area of Science:

Cardiovascular Electrophysiology
Cellular Biophysics

Background:

High-intensity electric shocks for defibrillation can cause arrhythmias and myocardial cell dysfunction.
This postshock cellular dysfunction is characterized by prolonged membrane depolarization and is linked to electromechanical breakdown.

Purpose of the Study:

To investigate rectangular biphasic waveforms for optimizing defibrillation efficacy.
To clarify the mechanism of postshock dysfunction in cultured myocardial cells.

Main Methods:

Cultured myocardial cells were stimulated with monophasic and various biphasic rectangular waveforms.
Postshock contractile activity arrest time was measured to assess cellular dysfunction.

Main Results:

Biphasic waveforms with up to 10% undershoot and 5-100 ms duration reduced arrest time by up to 50%.

Related Experiment Videos

Waveforms with greater than 20% undershoot increased postshock arrest duration.

Low-amplitude biphasic tails were found to ameliorate postshock dysfunction.

Conclusions:

Electromechanical breakdown of the myocardial cell membrane is a key factor in postshock dysfunction.
Optimized biphasic waveforms, particularly those with low-amplitude tails, can mitigate defibrillation-induced cellular dysfunction.