Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cochlear vascular and sensory cell changes induced by elevated temperature and noise.

L C Shaddock, R P Hamernik, A Axelsson

    American Journal of Otolaryngology
    |March 1, 1984
    PubMed
    Summary

    Noise-induced vascular changes in the chinchilla cochlea persisted for 45 days. Elevated body temperature did not interact with noise to affect vascular changes, but may have worsened hair cell loss at high noise levels.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Single auditory nerve fiber and action potential latencies in normal and noise-treated chinchillas.

    Hearing research·2026
    Same author

    Determination of the source location of anthropogenic radionuclides collected in Finland and Sweden in June 2020 using a multi-technology analysis.

    Journal of environmental radioactivity·2024
    Same author

    Third international challenge to model the medium- to long-range transport of radioxenon to four Comprehensive Nuclear-Test-Ban Treaty monitoring stations.

    Journal of environmental radioactivity·2022
    Same author

    Urologic, lymphedema, pelvic pain and gastrointestinal symptoms increase after radiotherapy in patients with primary uterine tumors: a prospective longitudinal Swedish cohort study.

    Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·2021
    Same author

    Measurement of radioxenon and radioargon in soil gas collected in the region of Kvarntorp, Sweden.

    Journal of environmental radioactivity·2020
    Same author

    A new method for analysis of beta-gamma radioxenon spectra.

    Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine·2019

    Area of Science:

    • Otoacoustic Emissions
    • Auditory Neuroscience
    • Vascular Biology

    Background:

    • Impulse noise exposure can cause cochlear damage.
    • Elevated body temperature is a potential confounding factor in noise-induced hearing loss studies.
    • Understanding vascular changes is crucial for assessing cochlear injury.

    Purpose of the Study:

    • To quantitatively analyze and compare cochlear vascular anatomy after impulse noise exposure.
    • To investigate the effects of normal versus elevated body temperatures on noise-induced vascular changes.
    • To correlate vascular changes with hair cell loss.

    Main Methods:

    • Chinchillas were exposed to 155- or 160-dB impulse noise at 37°C or 40°C.
    • Vascular anatomy was quantitatively analyzed 45 days post-exposure.

    Related Experiment Videos

  • Cochlear hair cell counts were assessed.

    • Main Results:

    • Persistent vascular changes were observed in all noise-exposed animals.
    • Six vascular variables (lumen irregularity, plasma spaces, RBC columns/density, pigment clumps, perivascular cell compression) were most affected.
    • Vascular changes indicated reduced blood flow and were most severe in areas of maximal hair cell loss.
    • No vascular interaction between noise and elevated temperature was found.
    • A potential interaction between high noise (160 dB) and high temperature (40°C) increased hair cell loss.

    Conclusions:

    • Impulse noise causes lasting vascular changes in the cochlea, suggesting impaired blood flow.
    • Elevated body temperature does not exacerbate noise-induced vascular damage but may worsen noise-induced hair cell loss at high intensities.